US federal regulators and more than 45 state prosecutors have sued Facebook, accusing the social media company of taking illegal actions to buy up rivals and stifle competition.
The lawsuits are one of the most significant legal actions the US government has taken against the firm.
Officials are asking the court to consider breaking up the company, which also owns Instagram and WhatsApp.
Facebook said the deals under scrutiny were approved by regulators years ago.
"The government now wants a do-over, sending a chilling warning to American business that no sale is ever final," Facebook general counsel Jennifer Newstead said.
She said the company had invested millions to make Instagram and WhatsApp successful and would defend itself "vigorously".
"Antitrust laws exist to protect consumers and promote innovation, not to punish successful businesses," Facebook said, describing the government's arguments as "revisionist history".
The lawsuits filed by the states and Federal Trade Commission (FTC) focus on Facebook's 2012 acquisition of Instagram, 2014 purchase of WhatsApp and rules governing outside software developers.
Officials accused Facebook of taking a "buy or bury" approach to potential rivals, hurting competitors and users, who have lost control of their own data to support the firm's advertising revenue.
The legal filings cite internal messages from Facebook boss Mark Zuckerberg, such as one 2008 email that said it was "better to buy than compete".
"For nearly a decade, Facebook has used its dominance and monopoly power to crush smaller rivals and snuff out competition, all at the expense of everyday users," said New York Attorney General Letitia James, who is leading the legal fight by the states.
"No company should have this much unchecked power over our personal interaction and social interactions. That's why we are taking action today."
The lawsuits come as US regulators are taking a closer look at the power enjoyed by tech companies.
This summer, the bosses of Google, Amazon, Facebook and Apple were forced to testify before Congress, as part of a bigger investigation of their influence on the market.
In October, the Department of Justice sued Google, accusing the search giant of violating US competition laws to maintain a monopoly on internet searches and online advertising.
More than 2.5 billion people use one of Facebook's apps each day. The firm, valued at nearly $800bn, employs more than 56,000 people and reported more than $18bn in profit last year.
The Open Markets Institute, a Washington think tank that has been pushing regulators to take a more aggressive stance against tech companies, said the lawsuits were a "critical step" forward.
"There's still more to do, but this is a big moment," the organisation wrote on Twitter.
BDST: 1330 HRS, DEC 10, 2020